The Role

Output has built a biological reasoning model that understands biology at the scale and complexity life actually operates. Our model independently learned the principles of molecular interactions, opening up drug treatments that were previously impossible. We're already generating therapies that traditional approaches cannot reach. The hardest problems in both AI and biology are being solved here, and you will be the reason the team can fully focus on solving them.
Output is currently in stealth, operated by a team of repeat founders and biotech veterans with multiple exits in AI x Bio, and backed by top-tier VCs including Y Combinator.

This is not a calendar-and-travel role. You will own the operations that everything else runs on, enabling the founders to operate at their highest level and the team to focus on science instead of logistics. On the business side, you keep our Union Square headquarters running smoothly. On the personal side, you keep the co-founders' professional and personal logistics organized. Every day will be different, and you will often be the one to figure out how. As the company grows, so will your role and opportunities.

• You will own day-to-day operations of our Union Square headquarters: supplies, building management liaison, vendor coordination from sourcing quotes to seeing work through, and first response for facility issues

• You will establish and document office procedures and SOPs where few exist today, and maintain and organize shared files, permissions, and templates in Google Drive and Notion

• You will handle administrative logistics, host visitors with warmth and polish, and own off-site planning end to end

• You will plan and execute company events, including recruiting-focused gatherings such as AI and biology evenings and founder dinners

• You will lead swag and brand/culture projects from design through delivery

• You will support onboarding as the team grows, making every new hire's first week seamless

• You will manage expenses and purchases through our neobank setup

• You will provide calendar management for the co-founders and travel coordination as needed

• You will assist the co-founders with drafting, reviewing, and polishing emails and other written content

• You will handle the co-founders' personal errands and life admin with discretion and good judgment, keeping their lives running seamlessly so they can focus on leading the company

About You

• You have at least 4 years of experience in operations, office management, executive or personal assistance, or workplace experience roles, with small-company or startup environments strongly preferred

• You are energized by a role that blends business and personal support. If you began in personal assistant or household management roles and moved into office operations, we encourage you to apply

• You approach operations as ownership, not task execution: you think about what the team needs before they ask, build systems instead of one-off fixes, and treat the office as your product

• You have a service mindset and take pride in the small details that make a big difference. You see what needs doing and do it without being asked

• You have exceptional written and verbal English, strong enough to draft and polish professional communications

• You are highly organized with excellent follow-through, and unflappable when plans change (and they will)

• You are discreet and trustworthy, comfortable working closely with a co-founding team and handling personal matters professionally

Bonus Points

• You have a background in business

• You have experience supporting founders or executives at an early-stage startup

• You have planned recruiting, community, or investor-facing events

• You have built office procedures, SOPs, or onboarding programs from scratch

Our Values

❤️ Heart: We foster a culture of ownership. We are assembling a team of individuals who are passionate and take pride in their contributions.

🏆 Excellence: We have an unwavering commitment to excellence and continuously challenge ourselves to reach the highest standards.

🚀 Practicality: We value practicality and results-oriented thinking. We are committed to making a tangible impact on the lives of patients and the broader community.

📣 Honesty: We place a high value on honesty and directness. We firmly believe in addressing issues as they arise, in an open and transparent manner.

🎮 Fun: We believe that life is too short to not have fun. Our goal is to create a workplace that is fun, engaging, rewarding and fulfilling.

What We Offer

• We encourage new and different ideas, creativity and contrarian thinking

• Healthy feedback focused environment to help you strive - leadership will have high expectations, regularly share constructive feedback, support you and help you grow, and welcome receiving feedback and ideas from you

• You own your day-to-day management. What we care about is that we all hit our milestones

• Competitive salary and equity in a growing, well-funded startup

• Excellent medical, dental, and vision coverage