Disruptive
Care
Consumer
Connection &Associate Director, Clinical Sciences
COMPASS Pathways
Company introduction:
Compass Pathways plc (Nasdaq: CMPS) is a biotechnology company dedicated to accelerating patient access to evidence-based innovation in mental health. The Company is headquartered in London, UK, with offices in New York City in the US. We focus on developing novel treatments that have the potential to improve the lives of those who are suffering with mental health conditions and who are not helped by current treatments.
We are pioneering a new paradigm for treating mental health conditions focused on rapid and durable responses through the development of our investigational COMP360 synthetic psilocybin treatment, potentially a first in class treatment. COMP360 has Breakthrough Therapy designation from the US Food and Drug Administration (FDA) and has received Innovative Licensing and Access Pathway (ILAP) designation in the UK for treatment-resistant depression (TRD) due to the pressing unmet need in this area.
We are currently in phase 3 for TRD, have completed phase 2 studies for both post-traumatic stress disorder (PTSD) and anorexia nervosa and are planning a further late-stage study in PTSD. We envision a world where mental health means not just the absence of illness but the ability to thrive. - Compass Pathways.
Job overview:
The Associate Director, Clinical Sciences is accountable for the scientific leadership and operational excellence of protocol strategy and clinical document development across assigned assets, ensuring robust clinical rationale, endpoint strategy, and patient-centered design aligned with regulatory and launch objectives.
The role partners closely with Clinical Operations, Statistics & Data Management, Medical Affairs, Regulatory Sciences, Clinical Safety, and HEOR to deliver high-quality protocols, IB/ICF content, and key clinical components of NDAs, enabling timely, compliant, and insight-driven decision making.
Location: Hybrid in our New York City office or remote on the East Coast in the United States.
Reports to: Vice President, Clinical Development.
Roles and responsibilities
(Include but are not limited to):
- Lead authorship and scientific integrity of clinical protocols, synopses, amendments, and key trial documents, integrating disease biology, patient journey insights, and regulatory feedback for psychiatric indications
- Lead SOPs, templates, and scalable processes that implement quality and velocity across the development portfolio
- Define study objectives, endpoints, inclusion/exclusion criteria, and statistical considerations in partnership with Statistics, aligning with target product profile and pivotal-readiness standards
- Drive cross-functional protocol development forums, ensuring timely input from all relevant functions, and resolving scientific and operational trade-offs with clear decision logs
- Contribute to NDA/MAA clinical components, including clinical summaries, study reports, and responses to regulatory queries
- Ensure evidence plans anticipate payer and access needs by partnering with HEOR/RWE to harmonize endpoints, PROs, and real-world relevance from protocol inception
- Champion patient-centric design, incorporating feasibility data, KOL feedback, and ethical considerations into procedures, visit schedules, and burden-reduction strategies
- Maintain scientific oversight during study execution, supporting medical monitoring, protocol deviations/clarifications, CSR quality, and interpretation of clinical signals across programs
- Lead cross-functional readiness for key milestones (protocol finalization, database lock, regulatory interactions), establishing operating rhythms and documentation standards consistent with Compass values and governance
- Partner with Medical Affairs to align on publication plans and scientific communication points derived from protocol design and study outcomes
- Accountable for compliance with ethical and scientific standards, regulatory requirements, and the Compass Quality Management System, ensuring participant safety, data integrity, and accuracy throughout the trial process.
Candidate Profile:
- PhD in neuroscience, pharmacology, or related life sciences field, or MD/PharmD with equivalent clinical development experience
- Required industry experience in biopharma/biotech clinical development with demonstrated leadership in protocol authorship and late-stage study design; CNS experience strongly preferred
- Preferable NDA/MAA experience, including contributing to Module 2/5 clinical sections, data narratives, and regulatory interaction support
- Proven capability to translate biology and patient insights into clear study objectives, endpoints, and operationally feasible designs in psychiatry/neurology
- Strong cross-functional collaboration; skilled at guiding teams through complex scientific choices and change
- Excellent scientific writing, data interpretation, and communication skills, with a track record of high-quality clinical documents and timely milestone delivery
- Mission-aligned, inclusive contributor who reflects Compass values and a wellbeing-first, stigma free culture
【For NYC】Compensation Description (annually):
Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, and work location.
Base pay is one part of the Total Package that is provided to compensate and recognise employees for their work and any role at Compass, regardless of the location, is eligible for additional discretionary bonuses and equity.
Benefits & Compensation:
For an overview of our benefits package and compensation information, please visit "Working at Compass".
Equal opportunities:
Reasonable accommodation
We are committed to building a workplace where everyone’s wellbeing matters. If you need reasonable accommodation during the interview process to be at your best, please let our recruiting team know.
UK applicants
We are proud of our commitment to diversity and equality (pursuant to the Equality Act 2010). We do not discriminate based upon race, religion or belief, colour, nationality, ethnic or national origin, gender, pregnancy or maternity, marital or civil partner status, sexual orientation, gender reassignment, age or disability.
US applicants
Compass Pathways is proud to be an equal opportunity employer. All employment decisions are based on business needs, job requirements, and individual qualifications, without regard to race, religion, color, national origin, sex (including pregnancy, childbirth, and related medical conditions), ethnicity, age, disability, sexual orientation, gender identity, gender expression, military service, genetic information, familial or marital status, or any other status, category, or characteristic protected by applicable law.
Sponsorship:
Unfortunately, we cannot sponsor employment visas and can only accept applications if you have employment rights in the country to which you are applying.
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